Setiawan, Herley Windo and Meliana, Resti Yudhawati and Syafaah, Irmi (2021) Association between serum PGE2 levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients. Annals of Medicine and Surgery, 71. ISSN 2049-0801

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Abstract

Background Mycobacterium tuberculosis that infected apoptotic macrophages is triggered by PGE2. Apoptosis suppresses the growth of Mycobacterium tuberculosis bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria. Objective Analyzing the association between serum PGE2 levels and the positivity of AFB in the sputum of tuberculosis patients. Methods A cross-sectional study was carried out from August 2019–July 2020. Serum PGE2 levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with p < 0.05. Results The average participants’ serum PGE2 levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE2 levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE2 levels and the degree of AFB positivity in sputum obtained r = −0.036 and p-value = 0.780. Conclusion There is a weak negative association between serum PGE2 levels and the degree of AFB positivity in sputum but not statistically significant.

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