Initial studyonTMPRSS2p.Val160Met genetic variantinCOVID-19patients Repository

Initial studyonTMPRSS2p.Val160Met genetic variantinCOVID-19patients

Laksmi Wulandari, ,- and BerlianaHamidah, ,- and CennikonPakpahan, ,- and NevyShintaDamayanti, ,- and NenengDewiKurniati, ,- and Christophorus OetamaAdiatmaja, ,- and MonicaRizkyWigianita, ,- and Soedarsono, ,- and DominicusHusada, ,- and Damayanti Tinduh, - and CitaRositaSigitPrakoeswa, ,- and AnangEndaryanto, ,- and NiNyomanTriPuspaningsih, ,- and Yasuko Mori, ,- and MariaIngeLusida, ,- and KazufumiShimizu, ,- and DelvacOceandy, ,- (2021) Initial studyonTMPRSS2p.Val160Met genetic variantinCOVID-19patients. Human Genomics, 15 (29). ISSN ISSN: 1479-7364

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Official URL: https://humgenomics.biomedcentral.com/articles/10....

Abstract

Background: Coronavirus disease2019(COVID-19)isaglobalhealthproblemthatcausesmillionsofdeaths worldwide. TheclinicalmanifestationofCOVID-19widelyvariesfromasymptomaticinfectiontoseverepneumonia and systemicinflammatorydisease.Itisthoughtthathostgeneticvariabilitymayaffectthehost’s responsetothe virus infectionandthuscauseseverityofthedisease.TheSARS-CoV-2virusrequiresinteractionwithitsreceptor complex inthehostcellsbeforeinfection.Thetransmembraneproteaseserine2(TMPRSS2)hasbeenidentifiedas one ofthekeymoleculesinvolvedinSARS-CoV-2virusreceptorbindingandcellinvasion.Therefore,inthisstudy, we investigatedthecorrelationbetweenageneticvariantwithinthehuman TMPRSS2 gene andCOVID-19severity and viralload. Results: We genotyped95patientswithCOVID-19hospitalisedinDrSoetomoGeneralHospitalandIndrapuraField Hospital (Surabaya,Indonesia)fortheTMPRSS2p.Val160Metpolymorphism.Polymorphismwasdetectedusinga TaqMan assay.Wethenanalysedtheassociationbetweenthepresenceofthegeneticvariantanddiseaseseverity and viralload.WedidnotobserveanycorrelationbetweenthepresenceofTMPRSS2geneticvariantandthe severity ofthedisease.However,weidentifiedasignificantassociationbetweenthep.Val160Metpolymorphism and theSARS-CoV-2viralload,asestimatedbytheCtvalueofthediagnosticnucleicacidamplificationtest. Furthermore, weobservedatrendofassociationbetweenthepresenceoftheCalleleandthemortalityratein patients withsevereCOVID-19. Conclusion: Our dataindicateapossibleassociationbetweenTMPRSS2p.Val160MetpolymorphismandSARS-CoV- 2 infectivityandtheoutcomeofCOVID-19.

Item Type:

Article

Uncontrolled Keywords:

COVID-19, TMPRSS2,Polymorphism

Subjects:

R Medicine > RC Internal medicine > RC705-779 Diseases of the respiratory system

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Paru

Creators:

Creators	NIM
Laksmi Wulandari, ,-	NIDN
BerlianaHamidah, ,-	UNSPECIFIED
CennikonPakpahan, ,-	UNSPECIFIED
NevyShintaDamayanti, ,-	UNSPECIFIED
NenengDewiKurniati, ,-	UNSPECIFIED
Christophorus OetamaAdiatmaja, ,-	UNSPECIFIED
MonicaRizkyWigianita, ,-	UNSPECIFIED
Soedarsono, ,-	UNSPECIFIED
DominicusHusada, ,-	UNSPECIFIED
Damayanti Tinduh, -	NIDN8889900016
CitaRositaSigitPrakoeswa, ,-	UNSPECIFIED
AnangEndaryanto, ,-	UNSPECIFIED
NiNyomanTriPuspaningsih, ,-	UNSPECIFIED
Yasuko Mori, ,-	UNSPECIFIED
MariaIngeLusida, ,-	UNSPECIFIED
KazufumiShimizu, ,-	UNSPECIFIED
DelvacOceandy, ,-	UNSPECIFIED

Depositing User:

Guruh Haris Raputra, S.Sos., M.M. '-

Date Deposited:

14 Nov 2022 10:40

Last Modified:

16 Nov 2022 05:34

URI:

http://repository.unair.ac.id/id/eprint/118652

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