Alexander Patera Nugraha, - and Agung Sosiawan, - and Amelia Aisyiah Anwar, - and Rifqah Ananda Mappananrang, - and Alqomariyah Eka Purnamasari, - and Nastiti Faradilla Ramadhani, - and Satutya Wicaksono, - (2022) Combination of anthocyanin ternatin and hydroxyapatite/β-tricalcium phosphate coralline as a socket preservation biomaterial in dental implant: A narrative review. World Journal of Advanced Research and Reviews, 16 (3). pp. 44-48. ISSN 2581-9615
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Abstract
Background: Tooth extraction is surgical treatment with clinical manifestation is alveolar bone resorption of 11-63% which potentially fails dental implant treatment. Socket preservation is bone regeneration treatment to minimize bone morphological changes in post-extraction using bone graft. Anti-inflammatory biomaterial is needed to modulate inflammatory cascade in the lesion. Anthocyanin ternatin is a flavonoid derived from butterfly pea (Clitoria ternatea) as an anti-inflammatory and antioxidants agent. Hydroxyapatite/β-Tricalcium Phosphate coralline (HA/β-TCP coralline) is a combination of bioceramic material from calcium carbonate heating of Porites spp. coral which has potential to induce osteogenesis, osteoinduction, and osteoconduction. Combination of Anthocyanin ternatin and HA/β-TCP coralline applied to the defect area in dried powder form to induce hard tissue regeneration. Purpose: To describe the potential of combination of Anthocyanin ternatin and HA/β-TCP coralline as a socket preservation biomaterial in dental implant. Review: Combination of Anthocyanin ternatin and dried powder HA/β-TCP coraline is applied in dental socket. Anthocyanin ternatin suppresses ROS and iNOS then inhibit NF-kB signaling pathway. Downregulation of the pathway decreases TNF-α and IL-1β/6 expression so the expression of RANKL is inhibited. Lowering of ROS followed by upregulated Ca2+ level from HA/β-TCP coralline causes the increase in DKK1 and PTEN expression so Akt and Wnt expression is induced. Upregulation of the proteins induces the BMP2/TGF-β/Smad1/5/8 signaling pathway activation manifest in the increase of Runx2, OCN, and Osx then the preosteoblast differentiation to osteoblast is increased. Conclusion: Combination of Anthocyanin ternatin and HA/β-TCP coralline is potential as socket preservation biomaterial in dental implant.
Item Type: | Article | ||||||||||||||||
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Uncontrolled Keywords: | Anthocyanin ternatin; Dental Implant; HA/β-TCP coralline; Medicine; Dentistry | ||||||||||||||||
Subjects: | R Medicine > RK Dentistry | ||||||||||||||||
Divisions: | 02. Fakultas Kedokteran Gigi > Dental Public Health | ||||||||||||||||
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Depositing User: | Muhammad Fadli Rois | ||||||||||||||||
Date Deposited: | 19 Dec 2022 01:34 | ||||||||||||||||
Last Modified: | 22 Dec 2022 06:46 | ||||||||||||||||
URI: | http://repository.unair.ac.id/id/eprint/119225 | ||||||||||||||||
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