Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials [version 1; peer review: 1 approved with reservations]

Gatot Soegiarto, - and Jonny Fajar, - and Laksmi Wulandari, - and Muhammad Anshory, - and Muhammad Ilmawan, - and Anisa Asmiragani, - and Himma Illiyana, - and Azaria Adam, - and Sutini Lamadi, - and Umi Sa'adah, - and Tubagus Yuantoko, - and Esi Nanda, - and Farida Rachmawati, - and Nabila Rahmadani, - and Randy Talilah, - and Madyline Katipana, - and Sharon Susanto, - and Maria Hindom, - and Ufi Anjasari, - and Nur Hidayah, - and Nanda Fadila, - and Vanela Lekatompessy, - and Uzi Phoenna, - and Fredo Tamara, - and Dessy Kartini, - and Aditya Mahendra, - and Andi Permana, - and Erwin Pasaribu, - and Kuldeep Dhama, - and Harapan, - (2022) Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials [version 1; peer review: 1 approved with reservations]. F1000Research, 11 (299). pp. 1-17. ISSN 2046-1402

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Official URL: https://f1000research.com/articles/11-299/v1

Abstract

BACKGROUND: The COVID-19 vaccination program, which uses various types of vaccines, has been applied since the beginning of 2021. However, the efficacy in the context of seroconversion rate remains unclear. OBJECTIVE: To assess the seroconversion rates among different COVID-19 vaccines using a network meta-analysis approach. METHODS: A network meta-analysis of randomized controlled trials (RCTs) was conducted during the study period. Data of interest, such as seroconversion rate and the type of COVID-19 vaccine, were extracted from each study. The analysis was performed using single-arm analysis by calculating the cumulative seroconversion rate. A network meta-analysis was conducted using the Bayesian method. RESULTS: A total of 31 RCTs were included in our analysis. Our pooled calculation revealed that the seroconversion rates of inactivated messenger ribonucleic acid (mRNA), protein subunit, and vector COVID-19 vaccines during the follow-up periods were 93.2%, 93.9%, 65.3%, and 54.7%, respectively, at ≤ 15 days; 96.0%, 94.8%, 91.2%, and 89.7%, respectively, between days 16–30; and 98.5%, 98.6%, 98.5%, and 96.2%, respectively, between days 31–60.The indirect comparison revealed that in the follow-up periods of ≤ 15 and 16–30 days, the inactivated and mRNA COVID-19 vaccines had superior seroconversion rates compared with those of the protein subunit and vector vaccines. In the follow-up period of 31–60 days, the highest seroconversion rates were found in the inactivated, mRNA, and protein subunit COVID-19 vaccines. CONCLUSION: This study provides valuable information regarding the comparison of seroconversion rates of COVID-19 vaccines.

Item Type: Article
Uncontrolled Keywords: COVID-19, vaccine, seroconversion, efficacy, immunization
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM
Gatot Soegiarto, -NIDN8888210016
Jonny Fajar, -UNSPECIFIED
Laksmi Wulandari, -NIDN8878210016
Muhammad Anshory, -UNSPECIFIED
Muhammad Ilmawan, -UNSPECIFIED
Anisa Asmiragani, -UNSPECIFIED
Himma Illiyana, -UNSPECIFIED
Azaria Adam, -UNSPECIFIED
Sutini Lamadi, -UNSPECIFIED
Umi Sa'adah, -UNSPECIFIED
Tubagus Yuantoko, -UNSPECIFIED
Esi Nanda, -UNSPECIFIED
Farida Rachmawati, -UNSPECIFIED
Nabila Rahmadani, -UNSPECIFIED
Randy Talilah, -UNSPECIFIED
Madyline Katipana, -UNSPECIFIED
Sharon Susanto, -UNSPECIFIED
Maria Hindom, -UNSPECIFIED
Ufi Anjasari, -UNSPECIFIED
Nur Hidayah, -UNSPECIFIED
Nanda Fadila, -UNSPECIFIED
Vanela Lekatompessy, -UNSPECIFIED
Uzi Phoenna, -UNSPECIFIED
Fredo Tamara, -UNSPECIFIED
Dessy Kartini, -UNSPECIFIED
Aditya Mahendra, -UNSPECIFIED
Andi Permana, -UNSPECIFIED
Erwin Pasaribu, -UNSPECIFIED
Kuldeep Dhama, -UNSPECIFIED
Harapan, -UNSPECIFIED
Depositing User: arys fk
Date Deposited: 24 Dec 2022 11:53
Last Modified: 24 Dec 2022 11:53
URI: http://repository.unair.ac.id/id/eprint/119283
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