The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model Repository

The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model

Waode Fifin Ervina, Waode and Aryati, Aryati and Yoes Prijatna Dachlan, Yoes and Iswinarno Doso Saputro, Iswinarno The Role of IL-27 as An Anti-Inflammatory in A Severe Burns Model. Indian Journal of Forensic Medicine & Toxicology, 15 (3). ISSN 09739122

	Text (Artikel) 18.pdf Download (902kB)
	Text (Turnitin) Turnitin.pdf Download (1MB)
	Text (Kualitas Karil & Kesesuaian Bidang Ilmu) 18. Validasi ( The Role of IL-27 as...).pdf Download (467kB)

Official URL: https://medicopublication.com/index.php/ijfmt/arti...

Abstract

AbstractActivation of IL27 can bind to one of its receptors gp130. This bond is able to regulate the signaling pathway and SOCS3 which plays a role in inhibiting the activation of proinflammatory cytokines such as TNF. In the case of burns, damaged cells potentially secrete the excessive pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1. These cytokines induce a SIRS which leads to sepsis causing multiple organ damage and death. This research aimed at proving the role of IL-27 as an anti-inflammatory to reduce TNF-α expression after severe burns. In this research I used laboratory experimental method. The research design was divided into 3 groups. The dorsal surfaces of mice were shaved to create a full-contact burn on approximately 28% of TBSA. The results of this research proved that IL-27 served as an anti-inflammatory agent through macrophage regulation to inhibit NF-kB activation because IL-27 has a gp 130 receptor which can induce the STAT3 signaling pathway and SOCS3. Key words: Interleukin-27, Burn Injury, TNF-α, SOCS3

Item Type:

Article

Subjects:

R Medicine > R Medicine (General) > R5-920 Medicine (General)

Divisions:

01. Fakultas Kedokteran > Bedah Plastik Rekonstruksi dan Estetik (Spesialis)

Creators: