Epy Muhammad Luqman, - and Widjiati, - and Eka Pramyrtha Hestianah, - and Gracia Angelina Hendarti, - and Lita Rakhma Yustinasari, - and Viski Fitri Hendrawan, - (2021) The Carbofuran Exposure During Lactation Period in Reducing the Motoric Reflexes and Memory in Infant Mice (Mus musculus). International Journal of Pharmaceutical Research, 13 (1). pp. 4831-4837. ISSN 0975-2366

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Abstract

This study aimed to determine the function of motoric reflexes and memory as a result of the necrosis of neuron cells in the cerebellum of infant mice (Mus musculus) from their carbofuran exposed mothers during lactation periods. The decreased motoric reflexes as an indicator of the reduced memory ability and concentration ability in infant mice. This experimental laboratory study used 36 mice and carbofuran injected using gavage method with the fraction of LD50 in mother mice in the dose of 5 mg/kg body weight (BW). The mother mice were exposed with carbofuran during lactation period from Day 0 to Day 9 and the 10-days-old infant mice were then terminated for microscopic examination by counting the necrosis of neuron cell by applying HE staining and the motoric-reflex function tests (neurobehavioral test) on the 10-days-old infant mice which included: surface righting reflexes, swimming and a memory test employing an Eight-arm radial maze at 20 days- old. The calculation results were analyzed using the Kruskal-Wallis test and the Mann Whitney test. The results of this study showed a significant increase in the necrosis of neuron cell, a fundamental decreased motoric reflex in infant mice in these activities; such as surface righting reflex and swimming ability (the head angle position and swimming direction) and eight-arm radial maze memory test. Conclusion: in sum, the exposure of carbofuran in the mother mice during lactation period causes the increase in necrosis of neuron cell, the decrease of motoric reflexes and the memory ability for infant mice

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