Riza Pratama Putra, - and Paulus Sugianto, - (2021) Acute Disseminated Encephalomyelitis (ADEM) as a Radiologic Finding of a HIV-infection with Cerebral Toxoplasmosis Infection. Annals of the Romanian Society for Cell Biology, 25 (6). pp. 20335-20339. ISSN 15836258

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Abstract

Toxoplasma gondii is a pathogenic opportunistic parasite that infect a range of hosts, including human of up to approximately one third of the human population. After the acute infection phase has passed, the parasite will remain in the host body as an intramuscular or intraneuronal cyst and it will be entirely controlled by the host immune system. Reactivation of cerebral toxoplasmosis in patients with immunodeficiency can result in severe immunopathologic response. We reported a case of a-40-year old male who had human immunodeficiency virus (HIV)with cerebral toxoplasmosis, the patient came with complaint of headache accompanied by multifocal neurologic deficits, with positive result on serologic test for Toxoplasma gondii, however the radiologic finding was acute disseminated encephalomyelitis (ADEM), which was not characteristic for cerebral toxoplasmosis. After adminitration of combination therapy regimen with pyrimethamine and clindamycin for six weeks, the patient showed clinical improvement of improved dysmetria, dysdiadokinesia and ataxia symptoms.

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