Dwi Murtiastutik, Dwi and Cita Rosita Sigit Prakoswa, Cita and Indah Setyawati Tantular, Indah and Evy Ervianti, Evy and Afif Nurul Hidayati, Afif and Muhammad Yulianto Listiawan, Muhammad Correlation between CD4 T lymphocyte and Candida Species Counts In Oral Candidiasis Patients with HIV / AIDS. Indian Journal of Forensic Medicine & Toxicology, 15 (1). ISSN 09739122

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Abstract

Abstract Background: Candida sp. is the most common opportunistic pathogen found during the development of Human immunodeficiency virus (HIV) & Acquired immune deficiency syndrome (AIDS) disease. The clinical severity of oral candidiasis and the prevalence profile of Candida species reflect immunological changes in HIV / AIDS patients. Objective: Evaluating the relationship between CD4 T lymphocyte cells counts and the number of Candida species. Methods: A cross-sectional analytical study was carried out at Dr. Soetomo, Surabaya, Indonesia. For identification of Candida species, culture was carried out on Chromagar media followed by culture with vitek 2. Results: There were 114 study subjects who were divided into three groups based on the number of CD4 T lymphocyte cells, with 158 isolates of Candida species growing in culture. The highest number of Candida species was Candida albicans with a total of 107 isolates (67.7%). Candida non-albicans were 51 isolates (32.3%). Statistical test results showed a significant correlation between the number of CD4 T lymphocyte cells and the number of Candida species (p <0.001). Conclusion: The decrease in CD4 lymphocyte cell counts is influenced by various types of Candida sp. in oral candidiasis patients.

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