Dwi Murtiastutik, Dwi and Cita Rosita Sigit Prakoswa, Cita and Indah Setyawati Tantular, Indah and Yusuf Wibisono, Yusuf and Afif Nurul Hidayati, Afif and Sawitri, Sawitri and Muhammad Yulianto Listiawan, Muhammad Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. Indian Journal of Forensic Medicine & Toxicology, 15 (1). ISSN 09739122

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Abstract

Abstract Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients. Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective: To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results: The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal effect is better than fluconazole.

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