Tutik Kusmiati, Tutik and Ni Made Mertaniasih, Ni Made and Johanes Nugroho Eko Putranto, Johanes and Budi Suprapti, Budi and Soedarsono, Soedarsono and Abdul Rahman Bahmid, Abdul A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report. Indian Journal of Forensic Medicine & Toxicology, 15 (4). ISSN 0973-9122

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Abstract

Abstract Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTc prolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-old woman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimen MDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurring at 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimen therapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimen MDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patients with QTc prolongation before changing the regiment.

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