Nabila Salsa Aryandri, - and Mia Ratwita Andarsini, - and Resti Yudhawati Meliana, - and Retno Asih Setyoningrum, - (2022) Correlation between Clinical and Laboratory Manifestation to The Severity and Outcome of COVID-19 Infection in Children with Cancer at RSUD Dr. Soetomo. International Journal of Research Publications, 115 (1). pp. 592-600. ISSN 2708-3578

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Abstract

COVID-19 infection in children is generally asymptomatic or with symptoms but milder than in adults, although symptoms of severe infection and death may also occur. Cancer patients have a high level of immunosuppression due to the anticancer therapy they are undergoing so that COVID-19 infection is more susceptible to complications. However, until now there have not been many reported cases of COVID-19 in pediatric patients with cancer, so it is not yet known whether there is a relationship between clinical and laboratory manifestations on the degree of severity and patient outcome. This study is an analytic observational study using a retrospective design, based on secondary data. Sampling was done by total sampling technique. Relationship analysis is used to answer the research hypothesis. To find out the relationship between variables, a chi-square and Fishers exact test was used because the data taken was nominal. Based on the inclusion and exclusion criteria, a total of 36 samples were found to fulfill. The most age range in patients was 3-5 years (36.11%) and was dominated by male sex (63.88%). From 36 samples, 21 of them had blood cancer, with the most type being ALL (90.47%). The degree of severity with the highest rate was moderate (37.83%) and most of the patient outcomes were alive (75%). The analysis carried out stated that there was no relationship between clinical manifestations and the severity of the patient. However, a relationship was found between shortness of breath symptoms and patient outcomes. Meanwhile, in laboratory manifestations there was no relationship between the degree of severity and the patients outcome. In conclusion, there is a relationship between symptoms of shortness of breath and the outcome of pediatric cancer patients with COVID-19 infection.

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