Lesni Untono, - (2005) Kadar C-Reactive Protein Serum Dan Jumlah Lekosit Dalam Darah P Ada Apendisitis Anak Hubungan Dengan Keadaan Akut Dan Perforasi. Thesis thesis, Universitas Airlangga.

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Abstract

Diagnosing acute appendicitis often difficult in children, especially in differing acute or perforated appendicitis because children cannot expressed their complaint and physical findings arenot specific . Negative appendectomy rates of I5-20 %, and negative laparotomy rates of 10-15 %. White Blood Cell count the most common laboratory test ordered, but its value is limited .CRP concentration increases within 8 hours of the onset of infection and remain high as long as there is continuing infection and tissue destruction.Prospective , from November 2004 until November 2005. Children that diagnosed with acute appendicitis, which included the criteria, blood sample were collected for serum CRP and leukocyte count, before perioperative antibiotic. After appendectomy, we performed histopathological examination. . The results of CRP, leucocyte and histopahological were analyzed Preoperatively , there were 30 children included , 25 children with acute appendicitis and 5 children with perforated appendicitis . Based on histopathological examination , there were 17 children with acute appendicitis and 13 children with perforated appendicitis. By using logistic regression, there is a correlation between CRP with perforated appendicitis and leukocyte count with perforated appendicitis. Cut off point for CRP is 40 and for leukocyte is 15.000. • It is required another diagnostic modality to prevent from misdiagnosis. • CRP and leukocyte count can be used as predictor of the occurance of perforated. appendicitis.

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