Jeffri, - (2009) Pengaruh Selang Penyalir Terhadap Proliferasi Fibroblas, Neovaskularisasi, Epitelisasi Dan Pertumbuhan Kuman Pada Luka. Thesis thesis, Universitas Airlangga.

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Abstract

There is a controversy in the use of drainage tube. Drainage tube is useful in draining blood and seroma after operation, but several expert revealed that drainage tube may hamper the wound healing process and increase susceptibility to microbial infection To prove the effect of drainage tube in fibroblast proliferation, neovascularization , epithelization and microbial growth on surgical wound. This is an experimental study with a randomized post test only control group design using experimental rabbit (Oryctalagus cuniculus). A surgical incision was performed up to subcutaneous tissue on the left and right lumbal region. The drainage tube was inserted on the right side wound and no drainage tube on the left side wound before closing the surgical wound. The second operation was performed 10 days after the first surgery. The surgical site on the left and right lumbal region were excised. With the filtration papers the deep surface of the both excised surgical sites were wiped off for microbial culture and the specimen margin were examined for fibroblast proliferation, neovascularization and epithelization using modified Greenhalg method. The two groups was analyzed using Wilcoxon Signed Rank test to check whether there is significant differences, the result showed that Z=-2,828 and p = 0,005 for fibroblast proliferation, Z=-2,828 and p =0,005 for neovascularization, and Z=-2,887 with p =0,004 for epithelization. There were significant difference between the two groups for these three variables, with the drainage tube group have lower scores. A significant difference between the two groups for microbial colonization was not found. Insertion of drainage tube in the surgical wound may decreased fibroblast proliferation,neovascularization , and epithelization, but did not increase the microbial growth.

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