Hernowo, - (2004) Ketorolac Mengurangi Kejadian Adhesi Pada Laparotomi Kelinci (Studi Comparasi Pad A Binatang Coba Kelinci). Masters thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Intraperitoneal adhesion is the most frequent cause of intestinal obstruction. The incident of adhesion remains high following laparatomy. There are many ways to reduce adhesion, among them is the administration of ketorolac. Objective : To evaluate the effectiveness of ketorolac in analgesic dosage to prevent intraperitoneal adhesion Material and method: This is a experimental study using rabbits. Twenty rabbits were divided into two groups. The first group was treated with subcutaneous injection of ketorolac lmglkg before undergoing laparotomy and intestinal milking, and was followed every 8 hours on the first postoperative day. The second group was treated as the control. A second laparotomy was performed' on each of the two groups, 10 days after the initial laparatomy. Intraperitoneal adhesion was evaluated by histopathologic examination. Result: Five (25%) rabbits experienced no adhesion, 11 (55%) rabbits had grade I adhesion and 4 (20%) rabbits demonstrated grade II adh~sion , Logistic regression statistical analysis did not reveal a significant difference (p=0,341) between the two groups. Conclusion : There was no difference in the formation of adhesion following laparotomy between the group of rabbits using ketorolac and that without ketorolac.

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