Firdalena Meutia, - (2001) Pengaruh Pemberian Ekstrak Urang-Aring (Eclipta Alba L Hassk) Terhadap Kadar SGOT / SGPT Dan Hispatologi Hepar Mencit Yang Diinduksi Dengan Karbon Tetraklorida. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Fifty male white mice (2 — 3 months old) were used in these experiment to study the effect of Eclipta alba L. Hassk extract on the level of SGOT / SGPT and the percentage of Iiver cell injury induced by Carbon Tetrachloride (CCI4). Mice were divided into five groups of ten each and were treated as follows: • Group Po as negative control were given CMC 1% for eight days. • Group P0.2 as positive control were given CMC 1% for eight days. • Group Pi : were given Eclipta alba L. Hassk extract 0.625 m919 Bw for eight days. • Group P2 : were given Eclipta alba L. Hassk extract 0.09375 mg/g Bw for eight days. • Group P3 eight days. At the 8m day were given CCI4 0.77 mg/g Bw to each group except the group Po was given coconut oil (as control group). This research is true experimental, the method used randomized, the post only controls group design. The mice were killed 10 days later, blood were processed to measure the level of SGOT / SGPT and the liver was cut and processed histologically. The histologically profile are norm cell, degeneration cell and picnotis cell. Statistical was performed using one way Anova with the next analysis is Least Significant Difference (LSD) (p < 0.05). The result showed that Eclipta alba L. Hassk at 0.0625 mg/g aw, 0 09375 nigig Bw, 0.125 mg/g Bw given for eight days significant affected (p < 0.05) to: elevation of the level of SGOT induced by CCI4 0.77 nigig aw. 2. Inhibt elevation of the level of SGPT induced by CCI4 0.77 mgig Bw 3. Inhibit elevation of the percentage of liver cell injury induced by CCI4 0.77 mg/g Bw

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