Muhammad Faris, Muhammad and Budi Utomo, Budi and Asra Al Fauzi, Asra and I Ketut Sudiana, I Ketut and Sri Maliawan, Sri and Yoes Prijatna Dahlan, Yoes and Oski Illiandri, Oski and Moh. Hasan Machfoed, Moh and Abdul Hafid Bajamal, Abdul ACTH4-PRO8-GLY9-PRO10 improves Neutrophil profile in spinal cord injury of rat models ‎. Turkish Neurosurgery, 11 (2). pp. 61-65. ISSN E-ISSN:2249-3379

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Abstract

Abstract Acute spinal cord injury (SCI) is a health burden that affects daily function. Based on its prevalence, SCI becomes a major problem in the country. Inflammation is one of SCI property that stays as the main target for management in the last decade. ACTH4-10PRO8-GLY9-PRO1 (Met-Glu-His-Phe-Pro-Gly-Pro) has been known for its anti-inflammatory properties but remains unclear for SCI models. This experimental study was done on the SCI model of the Sprague-Dawley rat. Neutrophil was taken as an inflammatory marker from the spinal cord of the rat model on 3 and 6 hours of observation following injury. Statistical analysis was done using ANOVA comparison test with significance cut off of p < 0.05, CI 95%. Six samples from each control and treatment group (normal saline 3 and 6 hours; ACTH4-10PRO8-GLY9-PRO10 3 and 6 hours) were observed for immunoreacted values of neutrophil staining to assess inflammatory reactions in spinal cord injury models. Statistical analysis continued with the Kruskal-Wallis test and found significant differences (p <0.001) between groups. Post-hoc tests were carried out using the Steel method. The most significant difference in Neutrophil levels was found in the ACTH4-10PRO8-GLY9-PRO10 6 hours group against normal saline 6 hours‎.

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