Saiku Akhmad Husen, - (2000) Pengaruh Paparan Benzopirin Terhadap Penurunan Respons Imun Mukosa Ileum Mencit (Mus musculus L): Pendekatan Patobiologik. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The influence of benzopyrene expostn"e on the decrease of mucosal immune response in ileum of mice was studied to demonstrate the reduction of immunocompetent cell components that may decrease mucosal immune response in the ileum of mice exposure benzopyTene in different dose, exposure period and combination of dose and exposure period. This study used 36 mice, which were divided into three dose group ( 0, 10, and 20 mglkg BW ). Each dose group was subdivided into 4 different period groups (1, 2, 4 and 8 weeks). In control group, olivarum oil was given orally to each mice, while in the treatment groups, benzopyrene solution of 10 mglkg BW (PI) and 20 mglkg BW (P2) as much as 0,2 ml was given orally to each mice during the determinant periods. Results showed that variables of lymphocyte, dose factor, exposure period and combination of dose and exposure period were significantly different. Variables of macrophage, dose factor were not significantly different, while period factor and combination of period and dose were significantly different Variables of active plasma cells, period factor were not signi11cantly different, while dose factor and combination of dose and peri ode were significantly different

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