Wahyu Hargiyanto, - and Viski Fitri Hendrawan, - and Widjiati, - and Epy Muhammad Luqman, - (2021) Hofbauer Cells and Nuclear Factor of Kappa Beta on Rat's Placenta that Black Carbon Exposure. International Journal of Pharmaceutical Research, 13 (1). pp. 4834-4844. ISSN 0975-2366

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Abstract

Increased oxidative stress is closely related to exposure to soot, one of which is through the activation of the Nuclear Factor-kappa Beta (NF-κB) will penetrate the placenta, thereby inducing the activity of macrophages (Hofbauer cells) and NF-κB in placental and fetal cells which results in increased necrosis and apoptosis. This study consisted of 42 pregnant white rats (Rattus norvegicus) divided into 3 groups: control (K0) not exposed to soot particulates, group 1 (K1) exposed to soot particulate by 532 mg/m3, group 2 (K2) exposed 1064 mg/m3 for 8 hours with long exposure of 6-11 and 6-17 during pregnancy. Placenta samples were examined by HE staining to count the number of Hofbauer cells and immunohistochemistry to see NFκB expression. The conclusion of this study was the number of Hofbauer cells has a tendency to increase with increasing doses and the length of time of exposure in the pregnancy period. Increased expression of NF-κB indicates inflammation caused by black carbon exposure to the placenta. Increasing the number of Hofbauer cells and NF-κB expression can affect pregnancy development

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