Savitri Laksmi Winaputri, Savitri and Dominicus Husada, Dominicus and Budi Utomo, Budi and Irene Ratridewi, Irene and Susanto Nugroho, Susanto and I Dewa Gede Ugrasena, I Dewa and Parwati Setiono Basuki, Parwati and Ismoedijanto, Ismoedijanto (2021) Microbiologically Documented Infection And Antimicrobial Sensitivities In Pediatric Malignancy Patients With Febrile Neutropenia At Dr Saiful Anwar Hospital, Malang, Indonesia. Jurnal Kedokteran Syiah Kuala, 20 (1). pp. 1-11. ISSN P-ISSN : 14421026 | E-ISSN : 25500112

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Abstract

Abstract Abstract. Background: Febrile neutropenia in malignancy children increase the risk of infection, morbidity and mortality. Microbiologically documented infection in pediatric malignancy has not been studied in Saiful Anwar Hospital. Purpose: Determine profile of blood, urine, sputum, and wound bed culture and antimicrobial sensitivities pattern in pediatric malignancy patients with febrile neutropenia. Methods: Pediatric malignancy patients with febrile neutropenia and microbiologically documented infection admitted to dr Saiful Anwar General Hospital Malang, were studied from 2016 to 2019. Bacterial and fungal etiology were identified, along with antimicrobial sensitivities patterns. Results: 53 (17%) of 307 pediatric malignancy patients with febrile neutropenia experienced 75 episodes of microbiologically documented infection. 40 (53,3%) gram-negative and 34 (45,3%) gram-positive isolated from 75 isolated pathogens. The most common gram-negative were Klebsiella pneumonia (n=15) and Escherichia coli (n=8). The most common gram-positive were Coagulase-negative Staphylococci (n=14) and Enterococcus faecalis (n=7). Escherichia coli, Coagulase-negative Staphylococci, Enterococcus faecalis, and Staphylococcus aureus were 100% sensitive to all tested antimicrobials. Klebsiella pneumonia and Acinetobacter baumanni were 100% sensitive to almost all tested antimicrobials. Pseudomonas aeruginosa was found less sensitive (0-80%) to all tested antimicrobials. Conclusion: Investigation of antimicrobial sensitivities of these organisms may guide successful antimicrobial therapy and improve quality of pediatric malignancy care.

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