Tomy Lesmana, - (2006) Hubungan Antara Kepadatan Mikrovaskuler Dengan Prognosis Berdasarkan Kriteria Ames Pada Karsinoma Tiroid Berdiferensiasi Baik. Masters thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Increasing of angiogenesis which measured by calculating microvascular density (MVD) is associated with the tendency of tumor to metastasize, recurrence and unfavourable prognosis. The prognosis of patients with well-differentiated thyroid carcinoma in dr.Soetomo General Hospital is detennined by the AMES criteria. Objective : To evaluate the correlation between MVD and prognosis based on AMES criteria in well-differentiated thyroid carcinoma. Method : This is a cross-sectional study. Microvascular density of well differentiated thyroid carcinoma specimens from the paraffin blocks were stained with factor VIII antigen an then counted using a light microscope under a 200 times magnification field . Prognosis of the related patients based on AMES criteria was noted from the medical records. All paraffin blocks of well-differentiated thyroid carcinoma tissue from the patients underwent surgery at dr.Soetomo General Hospital Surabaya from January 2005 to Febmary 2006 were included in this study. The data were analyzed and a linear regression statistical test with a significance level ofp<0.05 was used. Result : All specimens from patients with favourable prognosis demonstrated a MVD of :s;8 with a mean of 4.4±2.1 and all those with unfavourable prognosis showed a MVD of ~ 11 with a mean of 14.7±3.0 per field view. The mean ofMVD in papillary type thyroid carcinoma was 8.7±4.4 whereas in follicular type was 16.0±3.9 per field view. Conclusion : There is a correlation between MVD and unfavourable prognosis in well-differentiated thyroid carcinoma based on AMES c1iteria (p = 0.0001, correlation coefficient 0.74). The MVD in unfavourable prognosis was significantly higher than in favourable prognosis. The frequency of MVD in follicular type thyroid carcinoma was greater than papillary type (p = 0.0001, coefficient correlation 0.42)

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