Hubungan Antara Kepadatan Mikrovaskuler Dengan Prognosis Berdasarkan Kriteria Ames Pada Karsinoma Tiroid Berdiferensiasi Baik

Tomy Lesmana, - (2006) Hubungan Antara Kepadatan Mikrovaskuler Dengan Prognosis Berdasarkan Kriteria Ames Pada Karsinoma Tiroid Berdiferensiasi Baik. Masters thesis, UNIVERSITAS AIRLANGGA.

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Background : Increasing of angiogenesis which measured by calculating microvascular density (MVD) is associated with the tendency of tumor to metastasize, recurrence and unfavourable prognosis. The prognosis of patients with well-differentiated thyroid carcinoma in dr.Soetomo General Hospital is detennined by the AMES criteria. Objective : To evaluate the correlation between MVD and prognosis based on AMES criteria in well-differentiated thyroid carcinoma. Method : This is a cross-sectional study. Microvascular density of well differentiated thyroid carcinoma specimens from the paraffin blocks were stained with factor VIII antigen an then counted using a light microscope under a 200 times magnification field . Prognosis of the related patients based on AMES criteria was noted from the medical records. All paraffin blocks of well-differentiated thyroid carcinoma tissue from the patients underwent surgery at dr.Soetomo General Hospital Surabaya from January 2005 to Febmary 2006 were included in this study. The data were analyzed and a linear regression statistical test with a significance level ofp<0.05 was used. Result : All specimens from patients with favourable prognosis demonstrated a MVD of :s;8 with a mean of 4.4±2.1 and all those with unfavourable prognosis showed a MVD of ~ 11 with a mean of 14.7±3.0 per field view. The mean ofMVD in papillary type thyroid carcinoma was 8.7±4.4 whereas in follicular type was 16.0±3.9 per field view. Conclusion : There is a correlation between MVD and unfavourable prognosis in well-differentiated thyroid carcinoma based on AMES c1iteria (p = 0.0001, correlation coefficient 0.74). The MVD in unfavourable prognosis was significantly higher than in favourable prognosis. The frequency of MVD in follicular type thyroid carcinoma was greater than papillary type (p = 0.0001, coefficient correlation 0.42)

Item Type: Thesis (Masters)
Additional Information: PPDS. IB. 21/10 Les h
Uncontrolled Keywords: Well-differentiated thyroid carcinoma, MVD, AMES criteria
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: 01. Fakultas Kedokteran > Ilmu Bedah Umum
Tomy Lesmana, --
Depositing User: Dewi Puspita
Date Deposited: 05 Apr 2023 03:36
Last Modified: 05 Apr 2023 03:36
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