MYRNA ADIANTI, - (2008) HUBUNGAN INDEKS BAKTERIOLOGIS SAYATAN KULIT DAN CUPING TELINGA DENGAN TITER ANTIBODI IgM ADNTI PGL-1 PADA PENDERITA KUSTA BAARU DI RSUD Dr. SOETOMO SURABAYA. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

"Leprosy is a disease caused by Mycobacterium ieprae, also known as Hansen 's disease. Skin is the major area of infection manifestation, it can also cause nerve damages that can lead to abnormalities or deformities, especially on extremities. Laboratory diagnostic of leprosy is performed using microscope to find acid fast bacilli by calculating Bacteriological Index (BI) and serologically to examine anti PGL-I. This study will explore comparativeness between specimens extracted from ear lobe against specimen from other body surface skin lesion. IgM anti PGL-I will be a gold standard for diagnosis ofleprosy. This study was performed on a new leprosy patients visited Department of Skin and Venereology, Dr. Soetomo Hospital Surabaya, from October until December 2007, by cross sectional approach. The aim of this study is to find out correlation between BI and antibody IgM anti PGL-I titer. The specimens were taken as follow: I) slit-skin from ear lobe and 2) slit-skin from lesion in the body surfar ~ for Bacteriological Index examination; and 3) venous blood specimen for examine antibody IgM anti PGL-I. The results from 30 samples, 25 samples were leprosy patient MB type and 5 sample patients PB type. All leprosy PB types had shows BI 0 score. About 44% leprosy MB type shows BI 0 score from the ear lobe specimens, while 24% shows BI 0 score from the skin lesion specimens. The antibody IgM anti PGL-I titer from ELISA test was range from 131 - >6300 ulml, 5 samples were found to be the seronegatif «605 ulml), while the other 25 samples were seropositif (2':605 ulml). There is a significant correlation between BI ear lobe and BI skin lesion with antibody IgM anti PGL-I titer. The significances for BI skin lesion with antibody IgM anti PGL-I titer was r=0,580 (p=0,01) and for BI ear lobe with antibody IgM anti PGL-I titer was r=0,566 (p=0,0 I). This fmding shows that there are no differences between smear from skin lesion and ear lobe for diagnose of leprosy."

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