Erma Safitri, - and Thomas Valentinus Widiyatno, - and Willy Sandhika, - and R. Heru Prasetyo, - (2019) Effectivity of Honey to Regenerate The Production of Testosterone by Induction of Endogenous Stem Cells of Rat with Low Libido Due to Malnutrition. Biocell, 43 (4). pp. 235-239. ISSN 0327-9545 e-ISSN 1667-5746

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Abstract

The aim of the study was to know effectivity of honey from bee forest (Apis dorsato) to regenerate the production of testosterone by induction of endogenous stem cells of rat with low libido due to malnutrition. 40 rats as animal model were devided 4th groups: normal male rats without honey (C-) and 3th groups rats with low libido due to malnutrition were consists of without honey (C+), with 30% (v/v) honey (T1) and 50% (v/v) honey (T2) during 10 days. Low libido condition was induced by fasting without food during 5 days. Results: The improvement of libido was based on immunoreactivities of testosterone were detected in testis tissue. Testosterone expression as an immune response for regenerate signal in group C, C+, T1 and T2 respectively is 2.95 ± 0.15; 0.19 ± 0.55; 0.27 ± 0.45 and 2.05 ± 0.35. T1 and C+ were decreased significantly (p < 0.05) compared with C- and T2, while T2 didn't show decrease significantly (p > 0.05) compared with C-. The libido level were based 3 category of libido: the number of copulations, time of reaction and period of copulation. The T1 group was not increased of libido, while in the T2 group, there was an increased of libido that significant different (p<0.05) compared with T1 and C+. The conclusion is the 50% (v/v) honey from bee forest (Apis dorsata) can to be use regenerate the production of testosterone by induction of endogenous stem cells and improvement of libido of rat.

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