Doaa Elsayed Ramadan, - and Ninuk Hariyani, - and Retno Indrawati, - and Rini Devijanti Ridwan, - and Indeswati Diyatri, - (2020) Cytokines and Chemokines in Periodontitis. European Journal of Dentistry, 14 (3). ISSN 1305-7456

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Abstract

Periodontitis is a common inflammatory periodontal disease affecting a wide range of population all over the world. The causing bacteria releases chemicals which activate the innate immune system to release proinflammatory cytokines contributing to  more progression. This activates the acquired immune system leading to more progression of periodontitis. As the immune response goes on, released cytokines and chemokines can damage the periodontal ligaments, gingiva, and alveolar bone. There are many types of cytokines and chemokines in periodontitis. Cytokines are peptide mediators who are responsible for cell signaling and communication. Chemokines are a large subfamily of cytokines having the ability to coordinate leukocyte recruitment and activation. This paper is a narrative review of the literature.This review ensures that inflammatory mediators in the case of periodontitis can cause a noticeable damage in the whole apparatus of the periodontium. It causes soft tissue inflammation and bone damage affected by the mediators of both innate and acquired immune system.The inflammatory process is accompanied by large network of cytokines and chemokines. There is high expression of proinflammatory cytokines such as interleukin (IL)-1α, IL-1β, IL-6, IL-12, tumor necrosis factor (TNF)-α, and regulatory cytokines  such as IL-4, IL-1(RA) receptor antagonist, IL-10, and induced protein (IP)-10. There  is also increased production of cytokines IL-10, IL-12, interferon-γ, IP-10, IL-1RA, and  IL-4.  Cytokines  IL-17,  IL-6,  IL-1β,  TNF-α,  macrophage  colony-stimulating  factor,  and  prostaglandin E2 trigger the osteoclast activity causing bone resorption

Item Type:	Article
Subjects:	R Medicine > RK Dentistry
Divisions:	02. Fakultas Kedokteran Gigi > Dental Public Health
Creators:	Creators NIM Doaa Elsayed Ramadan, - - Ninuk Hariyani, - NIDN0007057906 Retno Indrawati, - NIDN0012115903 Rini Devijanti Ridwan, - NIDN0016126404 Indeswati Diyatri, - NIDN0015036204
Depositing User:	Muhammad Fadli Rois
Date Deposited:	14 Apr 2023 02:57
Last Modified:	14 Apr 2023 02:57
URI:	http://repository.unair.ac.id/id/eprint/123141
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