Chrismawan Ardianto, - and Hijrawati Ayu Wardani, - and Nurrahmi Nurrahmi, - and Mahardian Rahmadi, - and Junaidi Khotib, - (2020) Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice. Veterinary World, 13 (5). pp. 963-966. ISSN 0972-8988

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Abstract

Aim: This study examines the effect of alpha-lipoic acid (ALA) on sodium valproate-induced liver injury through histological features of mice liver tissue. Materials and Methods: Mice were divided into three groups; (1) vehicle group, (2) sodium valproate group, and (3) sodium valproate-ALA group. The vehicle group was injected with saline intraperitoneal (i.p.) for 28 days. The sodium valproate group was injected with sodium valproate 300 mg/kg, i.p. daily for 2 weeks, after which the vehicle was administered daily until day 28. The sodium valproate-ALA group was injected with sodium valproate 300 mg/kg daily for 2 weeks before the administration of ALA 100 mg/kg i.p. until day 28. The mice were euthanized, and the liver was extracted for histopathological examination. Results: Histopathological examination of the liver section of the vehicle group showed a normal structure of the liver. Two weeks after the administration of sodium valproate, histopathological examination showed an abnormal structure of the liver, with necrotic appearance and inflammatory cells. Moreover, treatment with ALA after the administration of sodium valproate notably ameliorated hepatic histopathological lesions and the liver structure corresponded to a normal liver structure. Conclusion: ALA ameliorates sodium valproate-induced liver injury in mice.

Item Type:	Article
Uncontrolled Keywords:	alpha-lipoic acid, drug-induced liver injury, histopathological, liver injury, sodium valproate.
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmasi Klinis
Creators:	Creators NIM Chrismawan Ardianto, - NIDN0029028403 Hijrawati Ayu Wardani, - - Nurrahmi Nurrahmi, - - Mahardian Rahmadi, - NIDN0014038102 Junaidi Khotib, - NIDN0022107001
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	15 Apr 2023 02:06
Last Modified:	28 Apr 2023 04:24
URI:	http://repository.unair.ac.id/id/eprint/123535
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