Dian Agustin Wahjuningrum, - and Setyabudi, - and Devi Eka Juniarti, - and Maulida Putri Syarifina, - and Brigitta Adela Rahmadita, - and Fery Setiawan, - (2022) The role of bioburden in the determination dose of γ irradiation. Bali Medical Journal (BaliMedJ).

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Abstract

Bone graft treatment is one of the treatments in dentistry that aims to prepare the condition of the alveolar bone before implant placement. Statistical data showed that more than two million procedures were carried out the bone grafts procedure. The bioburden method is used to determine the correct dose of γ-ray irradiation because the weakness of γ-ray irradiation can cause changes in mechanical properties, thereby reducing bone graft efficacy. The purpose of writing a review article was to discuss the determination of the irradiation dose using γ-rays based on the ISO 11137 standard and the sterility assurance level (SAL). All articles showed that determining the amount of initial contamination (bioburden) is important in determining the dose of γ-ray irradiation based on the SAL value. The first SAL value used was SAL 10-2 (verification dose) because from the verification dose obtained, it can be stated whether the irradiation dose using γ-rays is acceptable or not. SAL 10-2 is out of a hundred irradiated samples using γ-rays, only a maximum of 2 samples that are not sterile. If the SAL 10-2 value is accepted, the dose of γ-ray irradiation based on the SAL 10-6 value is accepted, but if it is not accepted, bone grafting must be done again. SAL 10-6 is the sterilization dose used when the product comes in contact with tissue or blood. The initial determination of the irradiation dose using γ-rays is finished by determining the amount of initial contamination (bioburden) so that the appropriate dose of γ-ray irradiation is obtained. The lower the bioburden level, the lower the dose of γ-ray irradiation used. The lower the dose of γ-ray irradiation, the lower the detrimental effects caused by γ-ray irradiation.

Item Type:	Article
Subjects:	R Medicine > RK Dentistry
Divisions:	02. Fakultas Kedokteran Gigi > Ilmu Konservasi Gigi (Spesialis)
Creators:	Creators NIM Dian Agustin Wahjuningrum, - NIDN0020087102 Setyabudi, - NIDN0029015405 Devi Eka Juniarti, - - Maulida Putri Syarifina, - - Brigitta Adela Rahmadita, - - Fery Setiawan, - -
Depositing User:	Muhammad Fadli Rois
Date Deposited:	17 Apr 2023 00:36
Last Modified:	17 Apr 2023 00:36
URI:	http://repository.unair.ac.id/id/eprint/123655
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