Devy Maulidya Cahyani, - and Andang Miatmoko, - and Berlian Sarasitha Hariawan, - and Kusuma Eko Purwantari, - and Retno Sari, - (2021) N-nitrosodiethylamine induces inflammation of liver in mice. Journal of Basic and Clinical Physiology and Pharmacology, 32 (4). pp. 505-510. ISSN 2191-0286

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Abstract

Objectives: For designing early treatment for liver cancer, it is important to prepare an animal model to evaluate cancer prevention treatment by using inflammation disease. The hepatocarcinogenic N-Nitrosodiethylamine (NDEA) has been reportedly able to produce free radicals that cause liver inflammation leading to liver carcinoma. This study aimed to evaluate the inflammation disease model of mice induced with hepatocarcinogenic NDEA for five weeks induction. Methods: The BALB-c mice were induced with NDEA 25 mg/kg of body weight once a week for five weeks intraperitonially and it was then evaluated for the body weight during study periods. The mice were then sacrificed and excised for evaluating their organs including physical and morphological appearances and histopathology evaluations. Results: The results showed a significant decrease of body weight of mice after five times induction of 25 mg NDEA/kgBW per week intraperitonially. Different morphological appearances and weight of mice organs specifically for liver and spleen had also been observed. The histopathology examination showed that there were hepatic lipidosis and steatohepatitis observed in liver and spleen, respectively that might indicate the hepatocellular injury. Conclusions: It can be concluded that inducing mice with NDEA intraperitonially resulted in fatty liver disease leading to progress of cancer disease.

Item Type:	Article
Uncontrolled Keywords:	cancer; inflammation; liver; mice; n-nitrosodiethylamine.
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM Devy Maulidya Cahyani, - - Andang Miatmoko, - NIDN0002108503 Berlian Sarasitha Hariawan, - - Kusuma Eko Purwantari, - - Retno Sari, - NIDN0008106303
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	16 Apr 2023 04:13
Last Modified:	16 Apr 2023 04:13
URI:	http://repository.unair.ac.id/id/eprint/123686
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