Tamara Yuanita, - and Lailatun Tedja, - and Debby Suryani, - and Irma Drismayanti, - (2021) Comparison of the Effect of Calcium Hydroxide Combination with Cocoa Pod Husk Extract and Green Tea Extract on Fibroblast and Alp Activation. Journal of International Dental and Medical Research. ISSN ISSN 1309-100X

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Abstract

To analyze the effect of the combination of calcium hydroxide with cocoa pod husk extract and calcium hydroxide with a combination of green tea extract on fibroblast and Alkaline Phospatase (ALP) activation in mice perforation dental pulp and Immunology. Sixty upper molars in Wistar rats were perforated mechanically and applied the combination material of pulp capping then divided into five groups. The first group was treated with calcium hydroxide and aqudes, the second group was treated with cocoa pod husk extract, the third group was treated with green tea extrac, the Fourth group was treated with calcium hydroxide and cocoa pod husk extract, the fifth group was treated with calcium hydroxide and green tea extract, then the cavity was restored. Rats from each group were killed after being treated according to a predetermined time by peritoneal injection to see the number of fibroblast cells and ALP activation. The average value of the number of fibroblasts in group I was lower compared to the other test groups. There were statistically significant differences between groups. between groups I with groups IV and V on day 7 and day 28 with p < 0.05. In ALP activation, the average value of ALP activation in group I was lower compared to the other test groups and there were statistically significant differences between groups group 1 and 4 other groups on day 7 and day 28. The expression of ALP in the wistar (rattus norvegicus) rat pulp after administration of calcium hydroxide mixed with green tea extract was higher than administration of calcium hydroxide mixed with cocoa pod extract. The use of combination calcium hydroxide with green tea extract has been proven to activate more ALP than the combination of calcium hydroxide with cocoa pod husk extract.

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