Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel

Noorma Rosita, - and Dewi Melani Hariyadi, - and Cordellia Calista Amelia, - and Alyajilan Madani Mamurrie, - and Andang Miatmoko, - (2022) Intravaginal delivery of reverse micellar epigallocatechin loaded in ĸ-carrageenan and HPMC K100M-based gel. Journal of Research in Pharmacy, 26 (4). pp. 849-858. ISSN 2630-6344

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Official URL: https://jrespharm.com/abstract.php?id=1070

Abstract

A gel with mucoadhesive properties and a controlled release profile is a suitable dosage form for reverse micellar EGCG delivery. In this study, ĸ-Carrageenan and HPMC K100M were used as the gel components at a weight ratio of 1:1.5, respectively, for loading native and reverse micellar EGCG. The characteristics of the gel were determined based on pH, swelling index, disintegration time, hardness, and entrapment efficiency. The in vitro EGCG release rate was further determined for EGCG levels. Moreover, in vivo cervical penetration studies of rhodamine-labeled EGCG gels in mice at two and six hours after intravaginal administrations were conducted. The results showed that the pH and hardness characteristics of the gels for each formula did not differ significantly, while the gel-loaded reverse micellar EGCG had a higher swelling index than that of native EGCG gels. In addition, the rate of release and cervical penetration of rhodamine-labeled reverse micellar EGCG loaded in gels was higher than those of rhodamine-labeled native EGCG gels. Therefore, it can be concluded that loading reverse micelles EGCG into gels prepared with ĸ-Carrageenan and HPMC K100M successfully controlled the release rate and improved cervical penetration, thereby enabling its potential use in cervical cancer treatment.

Item Type: Article
Uncontrolled Keywords: Epigallocatechin gallate; cancer; hydroxypropyl methylcellulose; κ-carrageenan; reverse micelle; cervical penetration
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM
Noorma Rosita, -NIDN0025126506
Dewi Melani Hariyadi, -NIDN0026027801
Cordellia Calista Amelia, --
Alyajilan Madani Mamurrie, --
Andang Miatmoko, -NIDN0002108503
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 16 Apr 2023 13:30
Last Modified: 16 Apr 2023 13:30
URI: http://repository.unair.ac.id/id/eprint/123743
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