Andang Miatmoko, - and Devy Maulidya Cahyani, - and Retno Widyowati, - (2022) Liposomes for Herbal Drug Delivery. In: Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part II. Bentham Science Publishers Pte. Lt, Singapore, pp. 227-258. ISBN 978-981-5036-55-8

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Abstract

This chapter evaluates liposomes used as delivery carriers for herbal products, which, due to poor permeability and solubility of extract components, has become a major issue in phytotherapy for treating illnesses and human health problems. Liposomes are vesicular formations with phospholipid bilayers that possess the capability to entrap both water-soluble and hydrophobic substances. However, there are several factors that should be considered with regard to herbal drugs, especially that the preparation technique should be appropriate to the solvent solubility of the plant extracts. In this regard, the ratio of phospholipids to extracts, pH stability, other liposomal components, and the ligand required to render liposome stability, circulation in the bloodstream for protracted periods, and targeted at specific organs should be investigated. The enhancement of phytochemical constituent stability within a context of environmental, physical, and chemical degradation, together with sustained or controlled drug release, can be achieved by incorporating extracts into liposomes. Moreover, the improved oral absorption of plant extracts by encapsulating them into liposomes indicates increased permeability and bioavailability via gastrointestinal tracts, thus enhancing pharmacological effects at low dose concentration as well as decreasing toxicity. However, thousands of constituents contained in plant extracts demonstrate various physicochemical characteristics that constitute significant challenges for liposomal delivery. Consequently, a comprehensive analysis of formulating and manufacturing aspects is required.

Item Type:	Book Section
Uncontrolled Keywords:	ioavailability, Human health, Illness, Liposomes, Phospholipids, Plant extracts, Solubility.
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmastika
Creators:	Creators NIM Andang Miatmoko, - NIDN0002108503 Devy Maulidya Cahyani, - - Retno Widyowati, - NIDN0005017701
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	16 Apr 2023 13:45
Last Modified:	12 May 2023 04:16
URI:	http://repository.unair.ac.id/id/eprint/123764
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