Fery Setiawan, - and Ahmad Yudianto, - and Dian Agustin Wahjuningrum, - and Jenny Sunariani, - (2021) Increase of CD 34 in Bone Defect Healing Lesions of Periodontitis by Capsaicin Administration. Journal of International Dental and Medical Research, 14 (3). ISSN 1309-100X

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Abstract

The relationship between the increase of CD 34 and TRPV-1 stimulation after being given by capsaicin in bone defect healing. Twenty-one male wistar rats were disorderly divided into three categories (each category=7): the first (K0=negative control), the second (K1=positive control), and the third (K2=treatment). Both K0 and K1 were only given with serotype b Aggregatibacter actinomycetemcomintas (A.a) to the cervical part of area of the first molar. The K2 category was given by serotype b A.a and cayenne pepper extract at dose 0.0912 mg/kg/day. After a week, the rats were sacrified using thionembutal with dose 30 mg/kg in accordance with their weight and for manufacturing sample specimen from gingival tissue region by immunology testing using immunohistochemical method. The acquired data were contrasted using a one-way Anova test. Result confirmed both TRPV-1 compute and CD-34 in K2 category to be prominent divergence in both TRPV-1 and CD-34 than K1 and K0 (p<0.05), whereas there was no prominent divergence between K1 and K0 (p>0.05). Capsaisin promotes the number of CD 34, angiogenesis factors, and microbial agents that it can be confirmed as the alternative treatment for bone defect healing caused by periodontitis.

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