Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

Alexander P. Nugraha, - and I G. A. W. Ardani, - and Ratri Maya Sitalaksmi, - and Nastiti F. Ramadhani, - and Desi Rachmayanti, - and Dina Kumala, - and Viol D. Kharisma, - and Desintya Rahmadani, - and Martining S. Puspitaningrum, - and Yuniar Rizqianti, - and Muhammad Dimas Aditya Ari, - and Albertus P. Nugraha, - and Tengku N. E. B. T. A. Noor, - and Muhammad Luthfi, - (2021) Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study. European Journal of Dentistry, 16. ISSN 1305-7456

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Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), ethanol extract may be beneficial as antioxidant, anti-inflammatory, induce osteogenic, and growth factor protein for anti–peri-implantitis. Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study. Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done.

Item Type: Article
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Prosthodontics
Alexander P. Nugraha, --
I G. A. W. Ardani, --
Ratri Maya Sitalaksmi, -NIDN0022108502
Nastiti F. Ramadhani, --
Desi Rachmayanti, --
Dina Kumala, --
Viol D. Kharisma, --
Desintya Rahmadani, --
Martining S. Puspitaningrum, --
Yuniar Rizqianti, --
Muhammad Dimas Aditya Ari, -NIM020911007
Albertus P. Nugraha, --
Tengku N. E. B. T. A. Noor, --
Muhammad Luthfi, -NIDN0006036704
Depositing User: Rudy Febiyanto
Date Deposited: 16 Apr 2023 13:10
Last Modified: 16 Apr 2023 13:10
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