Devi Rianti, - and Anita Yuliati, - and Ailani Sabrina, - and Kristanto Wahyudi, - and Herlina Damayanti, - (2020) THE ENHANCEMENT OF BONE DEFECT HEALING BY THE APPLICATION OF HYDROXYAPATITE EXTRACTED FROM INDONESIAN LIMESTONE. Biochem. Cell. Arch..

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Abstract

The purpose of this to examine the effect of hydroxyapatite extracted from Indonesian limestone on bone defects healing by means of the number of osteoblasts, fibroblasts and osteoclasts. This study design is an true experimental with randomized post-test only control group design. Femurs of eighteen Cavia cobaya were drilled to make bone defects and divided into 3 groups; group 1 (G1): defects without bone graft treatment, group2 (G2): bone defects were filled with bovine hydroxyapatite and group 3 (G3): bone defects were filled with Indonesian limestone.After 14 days, the animals were sacrificed and femurs were extracted. The numberof osteoblast, fibroblast and osteoclast were documented by histologically.The analysis of variance (ANOVA) continued by Least Significant Different (LSD) were conducted to analyze the data with p-value < 0.05 considered as statistically significant. The number of osteoblasts were higher in G3 than that in group G1 (p <0.05) but not with group G2 (p > 0.05). The number of osteoclasts were significantly lower in group G3 compared with group G1 and G2 (p<0.05). The number of fibroblast were higher in G3 than that in group G1 and group G2 (p<0.05). Hydroxyapatite from Indonesian limestone enhanced the bone deffect healing through the enhancement of osteoblasts, fibroblasts and reducement of osteoclasts number.

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