Qlaementine Ng Xue Qin, - and Long Chiau Ming, - and Mohd Shahezwan Abd Wahab, - and Ching Siang Tan, - and Ana Yuda, - and Andi Hermansyah, - (2023) Drug-related problems among older people with dementia: A systematic review. Research in Social and Administrative Pharmacy. ISSN 15517411 (In Press)

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Abstract

Introduction Dementia is a disorder that causes a decline of cognitive function, and it affects millions of people worldwide. Increased availability of medications used to treat dementia will inevitably increase the likelihood of drug-related problems (DRPs). Objective This systematic review sought to identify DRPs due to medication misadventures, including adverse drug reactions (ADRs), and use of inappropriate medications, among patients with dementia or cognitive impairments. Methods The included studies were retrieved from the electronic databases PubMed and SCOPUS, and a preprint platform (MedRXiv) which were searched from their inception through August 2022. The English-language publications that reported DRPs among dementia patients were included. The JBI Critical Appraisal Tool for quality assessment was used to evaluate the quality of studies included in the review. Results Overall, 746 distinct articles were identified. Fifteen studies met the inclusion criteria and reported the most common DRPs, which comprised medication misadventures (n = 9), such as ADRs, inappropriate prescription use, and potentially inappropriate medication use (n = 6). Conclusion This systematic review provides evidence that DRPs are prevalent among dementia patients, particularly the older people. It indicates that medication misadventures such as ADRs and inappropriate drug use, as well as potentially inappropriate medications, are the most prevalent DRPs among older people with dementia. Due to the small number of included studies, however, additional studies are required to improve comprehension about the issue.

Item Type:	Article
Uncontrolled Keywords:	Medication misadventureAdverse drug reactionsAlzheimer's diseaseHealthcare qualityHealth servicesDrug safetyMental health
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	05. Fakultas Farmasi > Farmasi Komunitas
Creators:	Creators NIM Qlaementine Ng Xue Qin, - - Long Chiau Ming, - - Mohd Shahezwan Abd Wahab, - - Ching Siang Tan, - - Ana Yuda, - NIDN0014027405 Andi Hermansyah, - NIDN0027098303
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	26 Apr 2023 05:56
Last Modified:	26 Apr 2023 05:56
URI:	http://repository.unair.ac.id/id/eprint/123993
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