Indah Asmara Gustarini, Indah and Audi Wahyu Utomo, Audi and Budi Sutikno, Budi and Achmad Chusnu Romdhoni, Achmad THE ASSOCIATION BETWEEN EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR WITH PRIMARY TUMOR VOLUME OF NASOPHARYNGEAL CARCINOMA PATIENTS. International Journal of NASOPHARYNGEAL CARCINOMA, 1. ISSN 2656-9027

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Abstract

Abstract Article Info Introduction: Nasopharyngeal carcinoma (NPC) is a malignancy derived from nasopharyngeal epithelial cells. One of the molecular NPC markers is cluster of Epidermal Growth Factor Receptor (EGFR) who have responsible against the proliferation, differentiation, apoptosis, metastasis and drug resistance. Objective: Tumor development was triggered by the excess population of the Epidermal Growth Factor Receptor (EGFR). EGFR expression associated with tumors size, positively nodules and advanced tumor stage in NPC patients. Methods: Using Cross-sectional as study design. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The expression of EGFR was studied with immunohistochemistry using EGFR polyclonal antibody (Bioss, USA). Assessment of the staining was performed by pathologist consultant used histoscore. The Pearson’s correlation test was used to determine the correlation between expression of EGFR and primary tumor volume of nasopharyngeal carcinoma. Statistical significance was defined as p <0.05. Result: Total samples are 19 patients. The result of EGFR expression in NPC patients with a primary tumor volume of 1-50 ml is 5 samples with a weak positive expression and 4 samples with moderate positive expression. NPC with a primary tumor volume of 51-100 ml is 2 samples of negative expression, 1 sample of weak positive expression, 3 samples with moderate positive expression and 2 samples with strong positive expression. NPC with primary tumor volume >100 ml is 1 sample weak positive expression and 1 sample strong positive expression. Statistical analysis using Pearson’s exact test was obtained p=0.047 with a correlation coefficient 0.461. EGFR expression from all of the patients there was 2 samples (10.53%) negatives, 7 samples (36.84%) weak positive, moderate positive was 7 samples (36.84%), and strong positive 3 samples (15.79%). Conclusion: There was an association between the expression of EGFR with the primary tumor volume of nasopharyngeal carcinoma.

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