Gwenny Ichsan Prabowo, Gwenny and Margarita Maria Maramis, Margarita and Erikavitri Yulianti, Erikavitri and Afrina Zulaikah, Afrina and Zain Budi Syulthoni, Zain and Citrawati Dyah Kencono Wungu, Citrawati and Hendy Muagiri Margono, Hendy and Retno Handajani, Retno Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia. In: Detection of COMTVal158Met Gene Polymorphism in Chronic Schizophrenic Patients at Psychiatric Unit of DR. Soetomo Hospital Surabaya, East Java, Indonesia. Universitas Airlangga. ISBN ISBN: 978-989-758-340-7

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Abstract

Schizophrenia is a complex and severe mental disorder which influences 0.5-1% of the global population. It is highly heritable and considered as a major health problem worldwide, including in Indonesia. The COMT Val158Met polymorphism is allegedly related to the schizophrenia predisposition. However, previous studies related to the COMT Val158Metpolymorphism among schizophrenic patients in different geographical areas have given different results. This research used cross-sectional study design. It applied a descriptive observational method which was aimed to detect the Val158Met COMT gene polymorphism in chronic schizophrenic patients. This study was conducted at the Psychiatric Unit of Dr. Soetomo Hospital Surabaya. The examination on COMT Val158Met polymorphism was conducted by PCR and followed by sequencing. The number of male chronic schizophrenic patients was higher than female (56.7 % over 43.3%) and the average age of male schizophrenic patients (38.53 ± 10.32 years old) was higher than female (41.08 ± 7.44 years old). Moreover, the number of schizophrenic patients with family history of schizophrenia reached 53.3%, which was higher than those without it, 46.7%. The PANNS total score of male schizophrenic patients reached 40.71 ± 16.07, which was higher than female, 40.31 ± 11.42. Furthermore, the sequencing analysis showed that the frequency of COMT Val158Metpolymorphism was 6.7% (2/30), the heterozygote allele was recorded at 21946 for 40% (12/30), and nucleotide substitution variant of T into A at 21971 was recorded at 3.3% (1/30) among chronic schizophrenic patients in the Psychiatric Unit of Dr. Soetomo Hospital Surabaya. There were quite large numbers of the COMTVal158Met polymorphism (6.7%), heterozygote allele at 21946 (40%), and nucleotide variant of T substitution into A at 21971 (3.3%) in chronic schizophrenic patients at the Psychiatric Unit of Dr. Soetomo Hospital Surabaya.

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