Eka Fitria Augustina, - (2020) EXPRESSION OF COX-2 ON DEFENSES OF THE GINGIVAL EPITHELIUM INJECTED WITH PORPHYROMONAS GINGIVALIS LIPOPOLYSACCHARIDE AFTER CURCUMIN ADMINISTRATION. Biochem. Cell. Arch, 20 (2). ISSN 0972-5075

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Abstract

The lipopolysaccharide (LPS) of Porphyromonas gingivalis is a crucial virulence factor critically involved in the regulation of immune inflammatory responses. Curcumin is a medicinal plant that can be used as an anti-inflammatory therapy. The aim of the study is to determine the role of COX-2 in the defense of the gingival epithelium in intervention by LPS P. gingivalis by administering curcumin. Forty wistar rats, aged 2-3 months divided into control and treatment group. which got 5 heads for each group. Animal production of gingivitis, performed by induction of LPS P. gingivalis is injected into the gingival sulcus of the mandibular incisor proximal portion and since 48 hours from injection of LPS P. gingivalis done giving curcumin. Days 1, 7 and 14, wistar is sacrificed according to the group and gingival epithelial tissue is taken for immunohistochemical examination procedure to determine expressions of COX-2. The result is COX-2 expression decreased after administration of curcumin in wistar treated with LPS Pg. Administration of curcumin in wistar rats after induction with LPS P. gingivalis decreased COX-2 expression. Decreased expression of inflammatory mediators can keep the gingival epithelial defenses.

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