Eka Fitria Augustina, - and Lambang Bargowo, - and Alfarabi Anhar, - and Dewi Nur Aini, - (2023) Inhibitory activity of jackfruit (Atrocarpus heterophyllus Lam.) leaf extract on the growth of Porphyromonas gingivalis bacteria. World Journal of Advanced Research and Reviews, 17 (1).

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Abstract

Background: Periodontitis is an inflammation that affects the periodontal tissue, causing pocket formation, loss of attachment, and tooth mobility. Periodontitis caused by a complex interaction between the body's immune response and microorganisms in dental plaque. One of the main agents in the etiology of chronic periodontitis is Porphyromonas gingivalis. Jackfruit (Atrocarpus heterophyllus Lam.) leaf contains active compounds such as saponin, flavonoid, and tannin. Objective: This study is aimed to determine the inhibition of jackfruit leaf extract (Atrocarpus heterophyllus Lam.) on the growth of Porphyromonas gingivalis bacteria. Method: This research is an in vitro laboratory experiment. Jackfruit leaf extraction was carried out by maceration method with 70% ethanol solvent, then diluted serially by dilution to obtain various concentrations. Concentrations used include 100%; 50%; 25%; 12.5%; 6.25%; 3.125%; 1.56%; and 0.78%. Inhibition test against Porphyromonas gingivalis bacteria was carried out by spectrophotometric method and colony count. Result: Jackfruit leaf extract with a concentration of 12.5%; 25%; 50%; and 100% can kill Porphyromonas gingivalis bacterial colonies resulting in 0 colonies. A concentration of 6.25% inhibited the growth of bacteria by 91.77%. The results of statistical tests obtained a significance value of 0.001 (P <0.05). Conclusion: Jackfruit leaf extract (Atrocarpus heterophyllus Lam.) has an inhibitory effect on the growth of Porphyromonas gingivalis bacteria with MIC values at a concentration of 6.25% and MBC at a concentration of 12.5%.

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