Widya Saraswati, - and Febriastuti Cahyani, - and Yovita Yonas, - and Saindra Arsa Gumilang, - and Yansha Mutia Dyah Kusumastuti, - and Nina Dhaniar, - and Hermawan Adi Praja, - (2020) EXPRESSION OF ENDOGENOUS ANTIOXIDANT IN DENTINE PULP COMPLEX AFTER HEMA RESIN APPLICATION. Biochem. Cell. Arch., 20 (2).

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Abstract

Free radicals can react with polyunsaturated acid in cellular membrane in DNA and caused cellular damage. In order to prevent tissue damage, reactive oxide metabolite should be eliminated through and enzymatic antioxidant such as superoxide dismutase (SOD), catalase, thioredoxin and glutathione peroxidase. Sprague Dawley rats were divided into 4 groups. 1 control group and 3 experimental groups. The tooth cavity in the control group was filled with glass ionomer cement without HEMAliquid resin.Tooth cavities in experimental groups were treated with HEMAliquid resin and then filled with glass ionomer cement. The teeth were extracted after 24, 48, and 72 hours. Immunohistochemistry staining was applied to investigate the expression of SOD and catalase. The observation was done under a light microscope. Test data were analyzed using the ANOVA test and Tukey HSD. Significant differences between SOD and Catalase were observed in the control group and experimental groups. There was no significant difference between the experimental groups (24, 48 and 72 hours). There was increased production of Catalase and SOD in dentine pulp complex after being applied with resin HEMA.

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