Romaniyanto, - and Cita Rosita Sigit Prakoeswa, - and Damayanti Tinduh, - and Hari Basuki Notobroto, - and Fedik Abdul Rantam, - and Dwikora Novembri Utomo, - and Heri Suroto, - and Ferdiansyah Mahyudin, - (2020) Intervertebral Disc Degeneration: Review Article. https://www.sysrevpharm.org/, 11 (11). pp. 1042-1049. ISSN 0976-2779

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Abstract

Intervertebral disc degeneration is one of the serious problems in vertebral system damage. Symptoms that late detected and similar with other vertebral diseases make this process such a "silent disease". There are several theories regarding the risk factors and mechanisms of intervertebral disc degeneration, ranging from exogenous or endogenous factors related to the structure of the disc, the annulus fibrosus and nucleus pulposus. Some examples of mechanisms that are often discussed are apoptosis, autophagy, pro-inflammatory cytokine storm and increased matrix catabolism. This pathological process will accelerate the disc cell senescence due to reduced proliferation, compromised self-repair, increased inflammatory response, and enhanced catabolic metabolism. This review article aims to discuss the mechanism of intervertebral disc degeneration from various possible causative factors and possible therapies that can be used in accordance with the cell degeneration mechanism.

Item Type:	Article
Subjects:	R Medicine
Divisions:	10. Fakultas Kesehatan Masyarakat > Biostatistika dan Kependudukan
Creators:	Creators NIM Romaniyanto, - - Cita Rosita Sigit Prakoeswa, - NIDN8865610016 Damayanti Tinduh, - NIDN8889900016 Hari Basuki Notobroto, - NIDN0025066504 Fedik Abdul Rantam, - NIDN0010035907 Dwikora Novembri Utomo, - NIDN8897700016 Heri Suroto, - NIDN8802630017 Ferdiansyah Mahyudin, - NIDN8890010016
Depositing User:	Tn Chusnul Chuluq
Date Deposited:	27 Apr 2023 02:17
Last Modified:	27 Apr 2023 02:17
URI:	http://repository.unair.ac.id/id/eprint/124865
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