Mochamad Rizki Yulianto, - and Agus Turchan, - and Hari Basuki Notobroto, - (2020) The Effect of Estrogen, Progesterone, and Its Combination on The Expression of Brain-Derived Neurotrophic Factor Medula Spinalis in Regeneration Process of Peripheral Nerve. Indian Journal of Forensic Medicine & Toxicology, 14 (4).

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Abstract

Background: The presence of modulation factors in the regeneration process of peripheral nerve cells influenced by estrogen and progesterone. Peripheral nerve injury is a fairly common case of trauma. Brainderived neurotrophic factor (BDNF) is the most active group of neurotrophins in stimulating neurogenesis. Objectives: To proves the effect of estrogen and progesterone on the expression of BDNF on the spinal cord in peripheral nerve regeneration process. Methods: Laboratory experimental study with the completely randomized design. Total transitory nerve ischiadicus was performed on four groups of rats. Each group received hormone therapy according to the group. Hormone therapy is administered every 3 days for 28 days, and on the 29th day is termination, spinal cord sampling, and followed by BDNF expression examination by Immunohistochemistry method. Results: In the control group, BDNF expression of spinal cord neuron cells was 93.0±14.0. In the treatment group, BDNF expression was obtained after strogen therapy was 77.25±19.19, progesterone was 84.5±20.61, and in a combination of estrogen and progesterone was 77.75±16.54. After statistical tests, no significant differences were found between the treatment groups (p = 0.316). Conclusion: The administration of estrogen, progesterone, or a combination of both did not significantly increase BDNF expression when compared to the control group.

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