Fabrication and Characterization of Submicron-Scale Bovine Hydroxyapatite: A Top-Down Approach for a Natural Biomaterial

Maria Apriliani Gani, - and Aniek Setiya Budiatin, - and Maria Lucia Ardhani Dwi Lestari, - and Fedik Abdul Rantam, - and Chrismawan Ardianto, - and Junaidi Khotib, - (2022) Fabrication and Characterization of Submicron-Scale Bovine Hydroxyapatite: A Top-Down Approach for a Natural Biomaterial. Materials, 15 (6). pp. 1-10. ISSN 1996-1944

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Official URL: https://www.mdpi.com/1996-1944/15/6/2324

Abstract

Submicron hydroxyapatite has been reported to have beneficial effects in bone tissue engineering. This study aimed to fabricate submicron-scale bovine hydroxyapatite (BHA) using the high-energy dry ball milling method. Bovine cortical bone was pretreated and calcined to produce BHA powder scaled in microns. BHA was used to fabricate submicron BHA with milling treatment for 3, 6, and 9 h and was characterized by using dynamic light scattering, scanning electron microscope connected with energy dispersive X-Ray spectroscopy, Fourier-transform infrared spectroscopy, and X-ray diffractometry to obtain its particle size, calcium-to-phosphorus (Ca/P) ratio, functional chemical group, and XRD peaks and crystallinity. Results showed that the particle size of BHA had a wide distribution range, with peaks from ~5 to ~10 µm. Milling treatment for 3, 6, and 9 h successfully gradually reduced the particle size of BHA to a submicron scale. The milled BHA’s hydrodynamic size was significantly smaller compared to unmilled BHA. Milling treatment reduced the crystallinity of BHA. However, the treatment did not affect other characteristics; unmilled and milled BHA was shaped hexagonally, had carbonate and phosphate substitution groups, and the Ca/P ratio ranged from 1.48 to 1.68. In conclusion, the fabrication of submicron-scale BHA was successfully conducted using a high-energy dry ball milling method. The milling treatment did not affect the natural characteristics of BHA. Thus, the submicron-scale BHA may be potentially useful as a biomaterial for bone grafts.

Item Type: Article
Uncontrolled Keywords: submicron material; nanomaterial; bone scaffold; bone graft; calcium phosphate; neglected disease
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM
Maria Apriliani Gani, --
Aniek Setiya Budiatin, -NIDN0012125911
Maria Lucia Ardhani Dwi Lestari, -NIDN0026048006
Fedik Abdul Rantam, --
Chrismawan Ardianto, -NIDN0029028403
Junaidi Khotib, -NIDN0022107001
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 28 Apr 2023 00:36
Last Modified: 28 Apr 2023 00:36
URI: http://repository.unair.ac.id/id/eprint/125204
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