Viability of α-mangostin and Lipopolysaccharide (LPS) in 7F2 Cells

Jauza A. Hermawan, - and Ristanty A.D. Uzmayana, - and Andra Rizqiawan, - and Retno Widyowati, - and Ta T. Tran, - (2023) Viability of α-mangostin and Lipopolysaccharide (LPS) in 7F2 Cells. Tropical Journal of Natural Product Research, 7 (1). pp. 2234-2236. ISSN 2616-0684

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Based on data from RISKESDAS in 2018, the incidence of tooth extraction in Indonesia is 19%. In post-extraction of teeth, the gingival tissue around the extraction area is inflamed as well as a decrease in the dimensions of the alveolar ridge. Socket preservation is performed to reduce the possibility of bone resorption and bone formation. Alpha(α)-mangostin from mangosteen peel extract (Garcinia mangostana Linn.) is expected to accelerate post-extraction healing so that implant placement can be more adequate. The study analyzed the viability of α-mangostin and lipopolysaccharide on 7F2 cells lines. Microtetrazolium (MTT) assay against 7F2 cell culture was used. The correlation between concentration and viability of Lipopolysaccharide (LPS) and α- mangostin was interpreted by statistical analysis. The viability of the 7F2 cell culture increased in line with the increase in the concentration of α-mangostin and the optimal concentration of 8.25 g/mL with the highest percentage of living cells at 132.120%. α-mangostin can increase the viability of 7F2 cell culture and it has the potential to be used as an alternative material to reduce inflammation after tooth extraction.

Item Type: Article
Uncontrolled Keywords: medicine, socket preservation, MTT assay, Lipopolysaccharide, α-mangostin
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Jauza A. Hermawan, --
Ristanty A.D. Uzmayana, --
Andra Rizqiawan, --
Retno Widyowati, -NIDN0005017701
Ta T. Tran, --
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 28 Apr 2023 04:29
Last Modified: 28 Apr 2023 04:29
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