Dwikora Novembri Utomo, Dwikora and Mohammad Zaim Chilmi, Mohammad and Angga Fiandana, Angga Effect of Platelet Rich Fibrin and Mesenchymal Stem Cell on Myoblast and Fibroblasts Ratio in Rabbit Muscle Defect. Journal Orthopaedi and Traumatology Surabaya, 7 (2). pp. 95-105. ISSN 2460-8742

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Abstract

Background: One of the problems in Orthopedics which often results in less satisfactory outcomes is the muscle injuries treatment. This is due to slow healing process and outcome has not been optimal because it produces scar tissue. Purpose: To evaluate effect of platelet rich fibrin and allogenic mesenchymal stem cell on muscle regeneration through comparation of myoblast and fibroblast ratio. Methods: This research is true experimental with randomized pre and post test with control group design. The treatment group included administering allogenic mesenchymal stem cells (MSC), rich fibrin platelets (PRF), and a combination of both. The study subjects were New Zealand White Rabbit which gastrocnemius muscle is incised. Muscle quality evaluation was done in the second and fourth weeks through histology examination in the form of myoblast cell ratio to fibroblast. Results: In the second week evaluation, administering allogenic MSC combined with PRF gave significant results to an increase in myoblast cell ratio to fibroblast. While evaluation of fourth week, giving of three treatment groups gave significant result to myoblast cell ratio to fibroblast. Conclusion: Allogenic MSC administration combined with PRF can improve New Zealand White Rabbit muscle healing quality by histological examination.

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