Kartika Wensdi Renantriandani and Ummi Maimunah and Priyo Budi Purwono and Retno Handajani (2020) The Appearance of Hbeag Status in Patients with Chronic Hepatitis B Virus. Indian Journal of Public Health Research & Development, 11 (6). pp. 1329-1335. ISSN 0976-0245, 0976-5506

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Abstract

Background: Chronic hepatitis B is a global burden disease with the mortality rate of over one million around the world because of the complication. In Indonesia the number of hepatitis B sufferers in a healthy population is estimated to reach 4-20.3%, where the figure is higher outside of Java. This study aims to analyze the description of HBeAg serological status in patients with chronic hepatitis B. Method: a descriptive study using medical records and sera of patients with chronic hepatitis B was used as primary data. The population of this study were patients with chronic hepatitis B in Gastroenterology and Hepatology Center of Dr. Soetomo General Hospital Surabaya in purposive sampling. The number of samples that fulfilled the inclusion and exclusion criteria was 82 people. Result: Most patients are between the ages of 50-59 (29,3%), males (67,1%), HbeAg loss (52,8%) receiving telbivudine (31,5%) and lamivudine (31,5%) as monotherapy for more than two years (42,1%) and have normal ALT (46,3%). Discussion: People with inactive (carriers) chronic HBsAg that are characterized by HBsAg last more than six months, also HBeAg negative, have serum ALT levels within normal limits. A temporary increase in ALT before remission can occur in some patients with chronic HBV infection after one year of treatment interruption. Conclusion: Telbivudine and lamivudine, separately as monotherapy, demonstrated greater HBeAg loss which reached within more than two years therapy.

Item Type:	Article
Uncontrolled Keywords:	chronic hepatitis B, HBeAg loss, ALT normalization, therapy
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Kartika Wensdi Renantriandani NIM011411131127 Ummi Maimunah NIDN8896900016 Priyo Budi Purwono NIDN0004088302 Retno Handajani NIDN8810523419
Depositing User:	Ika Rudianto
Date Deposited:	28 Apr 2023 08:07
Last Modified:	28 Apr 2023 08:07
URI:	http://repository.unair.ac.id/id/eprint/125531
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