Association of Liver Fibrosis based on Transient Elastography and Quantitative HbsAg Levels in HBeAg-Positive Chronic Hepatitis B Patients

Titong Sugihartono and Debrina Kusuma Devi and Ummi Maimunah and Iswan Abbas Nusi and Herry Purbayu and Ulfa Kholili and Budi Widodo and Muhammad Miftahussurur and Husin Thamrin and Amie Vidyani and Poernomo Boedi Setiawan (2020) Association of Liver Fibrosis based on Transient Elastography and Quantitative HbsAg Levels in HBeAg-Positive Chronic Hepatitis B Patients. International Journal of Pharmaceutical Research, 12 (4). pp. 1446-1451. ISSN 0975-2366

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Official URL: http://ijpronline.com/ViewArticleDetail.aspx?ID=17...

Abstract

Background: The data of lower quantitative hepatitis B surface antigen (HBsAg) level were associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B. This study aimed to analyze correlation between liver fibrosis based on transient elastography and quantitative HBsAg levels in HBeAg-positive chronic hepatitis B patients. Methods: We conducted a cross-sectional study of 32 treatment-naive HBeAg-positive chronic hepatitis B patients. Liver fibrosis was measured using transient elastography, and quantitative HBsAg level was measured using automated Chemiluminescence Enzyme Immunoassay. Results: Quantitative HBsAg levels were highest in the F1 group, followed by F2, F3 and lowest in the F4 group. A strong negative correlation between transient elastography and quantitative HBsAg level was revealed in HBeAg-positive chronic hepatitis B patients (r=-0.706, p=0.000). Quantitative HBsAg levels were found to be higher in the immune-tolerant phase which liver fibrosis was minimal compared to the immune clearance phase which liver fibrosis was more severe. Patients with more severe liver fibrosis showed lower quantitative HBsAg levels. Conclusion: We found a negative correlation between liver fibrosis based on transient elastography and quantitative HBsAg levels in HBeAg-positive chronic hepatitis B.

Item Type: Article
Uncontrolled Keywords: Liver fibrosis, transient elastography, quantitative HBsAg, chronic hepatitis B
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM
Titong SugihartonoNIDN8836800016
Debrina Kusuma DeviNIM011318026310
Ummi MaimunahNIDN8896900016
Iswan Abbas NusiNIDN0028025003
Herry PurbayuNIDN8884800016
Ulfa KholiliNIDN0004047511
Budi WidodoNIDN8804800016
Muhammad MiftahussururNIDN0029097909
Husin ThamrinNIDN8825800016
Amie VidyaniNIDN0028018002
Poernomo Boedi SetiawanNIDN8886900016
Depositing User: Ika Rudianto
Date Deposited: 28 Apr 2023 08:22
Last Modified: 28 Apr 2023 08:22
URI: http://repository.unair.ac.id/id/eprint/125537
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