Titong Sugihartono and Debrina Kusuma Devi and Ummi Maimunah and Iswan Abbas Nusi and Herry Purbayu and Ulfa Kholili and Budi Widodo and Muhammad Miftahussurur and Husin Thamrin and Amie Vidyani and Poernomo Boedi Setiawan (2020) Association of Liver Fibrosis based on Transient Elastography and Quantitative HbsAg Levels in HBeAg-Positive Chronic Hepatitis B Patients. International Journal of Pharmaceutical Research, 12 (4). pp. 1446-1451. ISSN 0975-2366

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Abstract

Background: The data of lower quantitative hepatitis B surface antigen (HBsAg) level were associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B. This study aimed to analyze correlation between liver fibrosis based on transient elastography and quantitative HBsAg levels in HBeAg-positive chronic hepatitis B patients. Methods: We conducted a cross-sectional study of 32 treatment-naive HBeAg-positive chronic hepatitis B patients. Liver fibrosis was measured using transient elastography, and quantitative HBsAg level was measured using automated Chemiluminescence Enzyme Immunoassay. Results: Quantitative HBsAg levels were highest in the F1 group, followed by F2, F3 and lowest in the F4 group. A strong negative correlation between transient elastography and quantitative HBsAg level was revealed in HBeAg-positive chronic hepatitis B patients (r=-0.706, p=0.000). Quantitative HBsAg levels were found to be higher in the immune-tolerant phase which liver fibrosis was minimal compared to the immune clearance phase which liver fibrosis was more severe. Patients with more severe liver fibrosis showed lower quantitative HBsAg levels. Conclusion: We found a negative correlation between liver fibrosis based on transient elastography and quantitative HBsAg levels in HBeAg-positive chronic hepatitis B.

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