Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis B patients

Titong Sugihartono and Ivan Pratama Alimsardjono and Ummi Maimunah and Iswan Abbas Nusi and Herry Purbayu and Ulfa Kholili and Budi Widodo and Muhammad Miftahussurur and Husin Thamrin and Amie Vidyani and Poernomo Boedi Setiawan (2020) Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis B patients. EurAsian Journal of BioSciences, 14. pp. 1745-1749. ISSN 1307-9867

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Official URL: https://ores.su/en/journals/eurasian-journal-of-bi...

Abstract

Background: Serum hyaluronic acid has an important role in the pathogenesis of liver fibrosis and is one of the most studied extracellular liver matrices. The purpose of this study was to examine the relationship between serum hyaluronic acid level and liver stiffness in hepatitis B chronic patients. Methods: This was an observational cross-sectional analytic study consisting of 43 samples of chronic hepatitis B patients. Serum hyaluronic acid was measured by the ELISA method. Liver stiffness describing fibrosis was examined using Fibro scan. Results: Among forty-three subject was predominantly by females (65.1%). The average age of the study subjects was 44.023 years old. The median serum hyaluronic acid level of the study subjects was 40.318 ng/mL. The median liver stiffness in the study subjects was 5.8 kPa. There was a significant positive correlation between serum hyaluronic acid levels and liver stiffness in the study subjects with a moderate strength of r = 0.448 (P = 0.003). Conclusion: Serum hyaluronic acid levels associated with liver stiffness.

Item Type: Article
Uncontrolled Keywords: hepatitis B virus infection, hyaluronic acid, liver stiffness
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM
Titong SugihartonoNIDN8836800016
Ivan Pratama AlimsardjonoUNSPECIFIED
Ummi MaimunahNIDN8896900016
Iswan Abbas NusiNIDN0028025003
Herry PurbayuNIDN8884800016
Ulfa KholiliNIDN0004047511
Budi WidodoNIDN8804800016
Muhammad MiftahussururNIDN0029097909
Husin ThamrinNIDN8825800016
Amie VidyaniNIDN0028018002
Poernomo Boedi SetiawanNIDN8886900016
Depositing User: Ika Rudianto
Date Deposited: 28 Apr 2023 08:54
Last Modified: 28 Apr 2023 08:54
URI: http://repository.unair.ac.id/id/eprint/125544
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