Yessy Puspitasari and Puspa Wardhani and Munawaroh Fitriah and Erik Hasudungan and Atika and Ummi Maimunah and Aryati (2021) Profile Quantitative Hepatitis B Surface Antigen (qHBsAg) of Chronic Naïve Hepatitis B Patients in Dr. Soetomo Hospital, Surabaya, Indonesia. Indian Journal of Forensic Medicine and Toxicology, 15 (2). pp. 3646-3652. ISSN p-0973-9122 and e-0973-9130

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Abstract

This study aimed to evaluate the profile of qHBs Ag profile, and also to investigate the correlation between qHBs Ag and HBV DNA. Seventy samples of chronic-naïve hepatitis B patients in Dr. Soetomo Hospital were analyzed in a cross-sectional study. Patients were categorized according to the HBe Ag positive (n=30) and HBe Ag negative (n=18), also based on qHBs Ag 1000 IU/mL and qHBs Ag >1000 IU/mL. qHBs Ag was correlated with HBV DNA. qHBs Ag by CLEIA method from Sysmex, KOBE HISCL, HBV DNA was measured by real-time Polymerase Chain method from Gene Xpert, Cepheid. 70 patients naïve CHB treatment showed a median of ALT level 60.21±70.76 U/L. 30 patients showed a positive-HBeAg, 18 patients showed negative-HBeAg, 22 patients were not evaluated (N/A). Positive-HBeAg patients had 70% qHBsAg >2500 mg/dL and median HBV DNA 7.49×107 IU/mL. Negative-HBeAg patients had 55.6% HBsAg ≤1000 mg/dL and median HBV DNA 9.66×102 IU/mL. qHBsAg correlated with HBV DNA (p <0.001). This data demonstrated that quantitative HBsAg was associated with a phase of HBV-infection, quantitative HBsAg showed a moderate correlation with DNA HBV, quantitative HBsAg levels might be a predictor of initiation therapy for CHB patients.

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