Muhammad Miftahussurur and Adinta Windia and Ari Fahrial Syam and Iswan Abbas Nusi and Ricky Indra Alfaray and Kartika Afrida Fauzia and Hartono Kahar and Herry Purbayu and Titong Sugihartono and Poernomo Boedi Setiawan and Ummi Maimunah and Ulfa Kholili and Husin Thamrin and Amie Vidyani and Dalla Doohan and Langgeng Agung Waskito and Yudith Annisa Ayu Rezkitha and Gontar Alamsyah Siregar and Yoshio Yamaoka (2021) Diagnostic Value of 14C Urea Breath Test for Helicobacter pylori Detection Compared by Histopathology in Indonesian Dyspeptic Patients. Clinical and Experimental Gastroenterology, 14. pp. 291-296. ISSN 1178-7023

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Abstract

Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as 14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and 14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The 14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population.

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